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Article

The p110α/ΔNp63α complex mutations in triple-negative breast cancer: Potential targets for transcriptional-based therapies.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jan 2023

Ma Wenqiong, Han Xingping, Shasaltaneh Marzieh Dehghan, Hosseinifard Hossein, Maghsoudloo Mazaher, Zhang Yuqin, Weng Qiao, Wang Qingjing, Wen QingLian, Imani Saber

Abstract excerpt

BACKGROUND: Hotspot mutations occurring in the p110α domain of the PIK3CA gene, specifically p110αH1047R/L increase tumor metastasis and cell motility in triple-negative breast cancer (TNBC). These mutations also affect the transcriptional regulation of ΔNp63α, a significant isoform of the p53 protein involved in cancer progression. This study attempts to investigate the transcriptional impact of p110αH1047R/L...

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PMID: 37980588
DOI: 10.3233/TUB-230013

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