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Article

PhysiBoSS: a multi-scale agent-based modelling framework integrating physical dimension and cell signalling.

Bioinformatics (Oxford, England) - 1 Apr 2019

Letort Gaelle, Montagud Arnau, Stoll Gautier, Heiland Randy, Barillot Emmanuel, Macklin Paul, Zinovyev Andrei, Calzone Laurence

Abstract excerpt

MOTIVATION: Due to the complexity and heterogeneity of multicellular biological systems, mathematical models that take into account cell signalling, cell population behaviour and the extracellular environment are particularly helpful. We present PhysiBoSS, an open source software which combines intracellular signalling using Boolean modelling (MaBoSS) and multicellular behaviour using agent-based modelling...

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PMID: 30169736
DOI: 10.1093/bioinformatics/bty766
PMCID: PMC6449758

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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