Simulating the impact of a molecular 'decision-process' on cellular phenotype and multicellular patterns in brain tumors.

Abstract excerpt

Experimental evidence indicates that human brain cancer cells proliferate or migrate, yet do not display both phenotypes at the same time. Here, we present a novel computational model simulating this cellular decision-process leading up to either phenotype based on a molecular interaction network of genes and proteins. The model's regulatory network consists of the epidermal growth factor receptor (EGFR), its...

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• Brain Neoplasms
• Cell Movement
• Decision Support Techniques
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