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Article

The Iron Chelator Deferiprone Improves the Phenotype in a Mouse Model of Tauopathy.

Journal of Alzheimer's disease : JAD - 1 Jan 2020

Rao Shalini S, Portbury Stuart D, Lago Larissa, Bush Ashley I, Adlard Paul A

Abstract excerpt

BACKGROUND: Abnormally hyperphosphorylated tau is a defining pathological feature of tauopathies, such as Alzheimer's disease (AD), and accumulating evidence suggests a role for iron in mediating tau pathology that may lead to cognitive decline in these conditions. The metal chelator deferiprone (DFP), which has a high affinity for iron, is currently in clinical trials for AD and Parkinson's disease. However, the...

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PMID: 32741833
DOI: 10.3233/JAD-200551

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