Article
Respiratory infection- and asthma-prone, low vaccine responder children demonstrate distinct mononuclear cell DNA methylation pathways.
Clinical epigenetics - 3 Jul 2024
Martino David, Schultz Nikki, Kaur Ravinder, van Haren Simon D, Kresoje Nina, Hoch Annmarie, Diray-Arce Joann, Su Jessica Lasky, Levy Ofer, Pichichero Michael
Abstract excerpt
BACKGROUND: Infants with frequent viral and bacterial respiratory infections exhibit compromised immunity to routine immunizations. They are also more likely to develop chronic respiratory diseases in later childhood. This study investigated the feasibility of epigenetic profiling to reveal endotype-specific molecular pathways with potential for early identification and immuno-modulation. Peripheral blood...
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