Article
Interferon-producing cells develop from murine CD31(high)/Ly6C(-) marrow progenitors.
Cellular immunology - 1 Aug 2006
Kreisel Friederike H, Blasius Amanda, Kreisel Daniel, Colonna Marco, Cella Marina
Abstract excerpt
In this study, we sorted total bone marrow (BM) into six distinct subsets based on surface expression of CD31 and Ly6C and investigated the capacity of these subsets to acquire characteristics of plasmacytoid dendritic cells (PDCs) after in vitro culture with FMS-like tyrosine kinase 3 ligand (Flt3-L). Cultured CD31(high)/Ly6C(-) cells were the only subset that consistently developed immunophenotypic, functional,...
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