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Article

The effect of acute morphine on obstructive sleep apnoea: a randomised double-blind placebo-controlled crossover trial.

Thorax - 1 Feb 2019

Rowsell Luke, Wong Keith K H, Yee Brendon J, Eckert Danny J, Somogyi Andrew A, Duffin James, Grunstein Ronald R, Wang David

Abstract excerpt

OBJECTIVE: Anaesthesiology guidelines suggest that opioids worsen obstructive sleep apnoea (OSA) despite no randomised controlled trial evidence. We therefore conducted a randomised controlled trial to evaluate the effects of a common clinical dose of morphine on OSA, and to identify clinical phenotype and genotype vulnerability to opioid-respiratory depression. METHODS: Under a double-blind, randomised,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 30166422
DOI: 10.1136/thoraxjnl-2018-211675

Genes

OPRM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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