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Article

Can variability in the effect of opioids on refractory breathlessness be explained by genetic factors?

BMJ open - 6 May 2015

Currow David C, Quinn Stephen, Ekstrom Magnus, Kaasa Stein, Johnson Miriam J, Somogyi Andrew A, Klepstad Päl

Abstract excerpt

OBJECTIVES: Opioids modulate the perception of breathlessness with a considerable variation in response, with poor correlation between the required opioid dose and symptom severity. The objective of this hypothesis-generating, secondary analysis was to identify candidate single nucleotide polymorphisms (SNP) from those associated with opioid receptors, signalling or pain modulation to identify any related to...

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Source

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Identifiers

PMID: 25948405
DOI: 10.1136/bmjopen-2014-006818
PMCID: PMC4431168

Genes

ARRB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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