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Article

Phenotyping interindividual variability in obstructive sleep apnoea response to temazepam using ventilatory chemoreflexes during wakefulness.

Journal of sleep research - 1 Dec 2011

Wang David, Marshall Nathaniel S, Duffin James, Yee Brendon J, Wong Keith K, Noori Nargis, Ng Susanna S W, Grunstein Ronald R

Abstract excerpt

Centrally active agents have a variable impact in patients with obstructive sleep apnoea (OSA) that is unexplained. How to phenotype the individual OSA response is clinically important, as it may help to identify who will be at risk of respiratory depression and who will benefit from a centrally active agent. Based on loop gain theory, we hypothesized that OSA patients with higher central chemosensitivity have...

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PMID: 21668806
DOI: 10.1111/j.1365-2869.2011.00931.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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