Article
Phenotyping interindividual variability in obstructive sleep apnoea response to temazepam using ventilatory chemoreflexes during wakefulness.
Journal of sleep research - 1 Dec 2011
Wang David, Marshall Nathaniel S, Duffin James, Yee Brendon J, Wong Keith K, Noori Nargis, Ng Susanna S W, Grunstein Ronald R
Abstract excerpt
Centrally active agents have a variable impact in patients with obstructive sleep apnoea (OSA) that is unexplained. How to phenotype the individual OSA response is clinically important, as it may help to identify who will be at risk of respiratory depression and who will benefit from a centrally...
Topics
- Adult
- Cross-Over Studies
- Double-Blind Method
- Humans
- Hypnotics and Sedatives
- Male
- Phenotype
- Polysomnography
- Respiration
- Sleep
- Sleep Apnea, Obstructive
- Temazepam
- Wakefulness