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Article

Targeted Gene Sequencing in Children with Crohn's Disease and Their Parents: Implications for Missing Heritability.

G3 (Bethesda, Md.) - 30 Aug 2018

Chen Jiun-Sheng, Hu Fulan, Kugathasan Subra, Jorde Lynn B, Nix David, Rutherford Ann, Denson Lee, Watkins W Scott, Prahalad Sampath, Huff Chad, Guthery Stephen L

Abstract excerpt

Crohn's disease is a complex genetic trait characterized by chronic relapsing intestinal inflammation. Genome wide association studies (GWAS) have identified more than 170 loci associated with the disease, accounting for ∼14% of the disease variance. We hypothesized that rare genetic variation in GWAS positional candidates also contribute to disease pathogenesis. We performed targeted, massively-parallel...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30166421
DOI: 10.1534/g3.118.200404
PMCID: PMC6118318

Genes

NOD2
MGAT3
RTKN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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