Article
Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor.
Proceedings of the National Academy of Sciences of the United States of America - 29 Mar 2016
Song Min-Suk, Kumar Gyanendra, Shadrick William R, Zhou Wei, Jeevan Trushar, Li Zhenmei, Slavish P Jake, Fabrizio Thomas P, Yoon Sun-Woo, Webb Thomas R, Webby Richard J, White Stephen W
Abstract excerpt
The influenza endonuclease is an essential subdomain of the viral RNA polymerase. It processes host pre-mRNAs to serve as primers for viral mRNA and is an attractive target for antiinfluenza drug discovery. Compound L-742,001 is a prototypical endonuclease inhibitor, and we found that repeated passaging of influenza virus in the presence of this drug did not lead to the development of resistant mutant strains....
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