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Article

Inhibition of HIV-1 replication by amphotericin B methyl ester: selection for resistant variants.

The Journal of biological chemistry - 29 Sept 2006

Waheed Abdul A, Ablan Sherimay D, Mankowski Marie K, Cummins James E, Ptak Roger G, Schaffner Carl P, Freed Eric O

Abstract excerpt

Membrane cholesterol plays an important role in human immunodeficiency virus type 1 (HIV-1) particle production and infectivity. Here, we have investigated the target and mechanism of action of a cholesterol-binding compound, the polyene antifungal antibiotic amphotericin B methyl ester (AME). We found that AME potently inhibited the replication of a highly divergent panel of HIV-1 isolates in various T-cell...

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Identifiers

PMID: 16882663
DOI: 10.1074/jbc.M603609200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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