Article

Influenza A virus resistance to 4’-fluorouridine coincides with viral attenuation <i>in vitro</i> and <i>in vivo</i>

2023-10-21

Abstract excerpt

Pre-existing or rapidly emerging resistance of influenza viruses to approved antivirals makes the development of novel therapeutics to mitigate seasonal influenza and improve preparedness against future influenza pandemics an urgent priority. We have recently identified the chain-terminating broad-spectrum nucleoside analog clinical candidate 4’-fluorouridine (4’-FlU) and demonstrated oral efficacy against seasona...

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Literature Corpus work: be979e35-f171-5287-ab6c-06f218c4396b
DOI: 10.1101/2023.10.20.563370

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