A genome-wide association study identifies three novel genetic markers for response to tamoxifen: A prospective multicenter study.

doi:10.1371/journal.pone.0201606

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Article

A genome-wide association study identifies three novel genetic markers for response to tamoxifen: A prospective multicenter study.

PloS one - 1 Jan 2018

Onishi Hiroshi, Udagawa Chihiro, Kubo Michiaki, Nakamura Seigo, Akashi-Tanaka Sadako, Kuwayama Takashi, Watanabe Chie, Takamaru Tomoko, Takei Hiroyuki, Ishikawa Takashi, Miyahara Kana, Matsumoto Hiroshi, Hasegawa Yoshie, Momozawa Yukihide, Low Siew-Kee, Kutomi Goro, Shima Hiroaki, Satomi Fukino, Okazaki Minoru, Zaha Hisamitsu, Onomura Mai, Matsukata Ayami, Sagara Yasuaki, Baba Shinichi, Yamada Akimitsu, Shimada Kazuhiro, Shimizu Daisuke, Tsugawa Koichiro, Shimo Arata, Hartman Mikael, Chan Ching-Wan, Lee Soo Chin, Endo Itaru, Zembutsu Hitoshi

Abstract excerpt

PURPOSE: Although association studies of genetic variations with the clinical outcomes of breast cancer patients treated with tamoxifen have been reported, genetic factors which could determine individual response to tamoxifen are not fully clarified. We performed a genome-wide association study (GWAS) to identify novel genetic markers for response to tamoxifen. EXPERIMENTAL DESIGN: We prospectively collected 347...

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PMID: 30161160
DOI: 10.1371/journal.pone.0201606
PMCID: PMC6116947

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