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Article

Genome-wide discovery of genetic variants affecting tamoxifen sensitivity and their clinical and functional validation.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Jul 2013

Weng L, Ziliak D, Im H K, Gamazon E R, Philips S, Nguyen A T, Desta Z, Skaar T C, Flockhart D A, Huang R S

Abstract excerpt

BACKGROUND: Beyond estrogen receptor (ER), there are no validated predictors for tamoxifen (TAM) efficacy and toxicity. We utilized a genome-wide cell-based model to comprehensively evaluate genetic variants for their contribution to cellular sensitivity to TAM. DESIGN: Our discovery model incorporates multidimensional datasets, including genome-wide genotype, gene expression, and endoxifen-induced cellular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23508821
DOI: 10.1093/annonc/mdt125
PMCID: PMC3690911

Genes

USP7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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