Article
A genome-wide association study identifies locus at 10q22 associated with clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients in Japanese.
Human molecular genetics - 1 Apr 2012
Kiyotani Kazuma, Mushiroda Taisei, Tsunoda Tatsuhiko, Morizono Takashi, Hosono Naoya, Kubo Michiaki, Tanigawara Yusuke, Imamura Chiyo K, Flockhart David A, Aki Fuminori, Hirata Koichi, Takatsuka Yuichi, Okazaki Minoru, Ohsumi Shozo, Yamakawa Takashi, Sasa Mitsunori, Nakamura Yusuke, Zembutsu Hitoshi
Abstract excerpt
Although many association studies of polymorphisms in candidate genes with the clinical outcomes of breast cancer patients receiving adjuvant tamoxifen therapy have been reported, genetic factors determining individual response to tamoxifen are not fully understood. To identify genetic polymorphisms associated with clinical outcomes of patients with tamoxifen treatment, we conducted a genome-wide association...
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