Article
A genome-wide association study to identify genetic susceptibility loci that modify ductal and lobular postmenopausal breast cancer risk associated with menopausal hormone therapy use: a two-stage design with replication.
Breast cancer research and treatment - 1 Apr 2013
Hein Rebecca, Flesch-Janys Dieter, Dahmen Norbert, Beckmann Lars, Lindström Sara, Schoof Nils, Czene Kamila, Mittelstraß Kirstin, Illig Thomas, Seibold Petra, Behrens Sabine, Humphreys Keith, Li Jingmei, Liu Jianjun, Olson Janet E, Wang Xianshu, Hankinson Susan E, Truong Thérèse, Menegaux Florence, Dos Santos Silva Isabel, Johnson Nichola, Chen Shou-Tung, Yu Jyh-Cherng, Ziogas Argyrios, Kataja Vesa, Kosma Veli-Matti, Mannermaa Arto, Anton-Culver Hoda, Shen Chen-Yang, Brauch Hiltrud, Peto Julian, Guénel Pascal, Kraft Peter, Couch Fergus J, Easton Douglas F, Hall Per, Chang-Claude Jenny
Abstract excerpt
Menopausal hormone therapy (MHT) is associated with an elevated risk of breast cancer in postmenopausal women. To identify genetic loci that modify breast cancer risk related to MHT use in postmenopausal women, we conducted a two-stage genome-wide association study (GWAS) with replication. In stage I, we performed a case-only GWAS in 731 invasive breast cancer cases from the German case-control study Mammary...
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