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Article

Affinity maturation and characterization of the ofatumumab monoclonal antibody.

Journal of cellular biochemistry - 1 Jan 2019

Payandeh Zahra, Rajabibazl Masoumeh, Mortazavi Yousef, Rahimpour Azam, Taromchi Amir Hossein, Dastmalchi Siavoush

Abstract excerpt

CD20 molecule, a phosphoprotein with 297 amino acids and four transmembrane domains, is a member of MS4A protein family. Anti-CD20 antibodies such as ofatumumab, which have been developed for cancer treatment and has demonstrated efficacy in relapsed/refractory chronic lymphocytic leukemia, are among the most successful therapies to date. Rational engineering methods can be applied with reasonable success to...

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Share to Antibodies, Monoclonal, Humanized
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Identifiers

PMID: 30160776
DOI: 10.1002/jcb.27457

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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