Article
Pallidin is a novel interacting protein for cytohesin-2 and regulates the early endosomal pathway and dendritic formation in neurons.
Journal of neurochemistry - 1 Oct 2018
Ito Akiko, Fukaya Masahiro, Saegusa Shintaro, Kobayashi Emi, Sugawara Takeyuki, Hara Yoshinobu, Yamauchi Junji, Okamoto Hirotsugu, Sakagami Hiroyuki
Abstract excerpt
Cytohesin-2 is a member of the guanine nucleotide exchange factors for ADP ribosylation factor 1 (Arf1) and Arf6, which are small GTPases that regulate membrane traffic and actin dynamics. In this study, we first demonstrated that cytohesin-2 localized to the plasma membrane and vesicles in various subcellular compartment in hippocampal neurons by immunoelectron microscopy. Next, to understand the molecular...
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