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Inhibition of Cytohesins Protects against Genetic Models of Motor Neuron Disease

17 Jun 2015

Abstract excerpt

Mutant genes that underlie Mendelian forms of amyotrophic lateral sclerosis (ALS) and biochemical investigations of genetic disease models point to potential driver pathophysiological events involving endoplasmic reticulum (ER) stress and autophagy. Several steps in these cell biological processes are known to be controlled physiologically by small ADP-ribosylation factor (ARF) signaling. Here, we investigated...

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PMID: 26085633
DOI: 10.1523/jneurosci.5032-13.2015

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