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Article

Targeting IGF Perturbs Global Replication through Ribonucleotide Reductase Dysfunction.

Cancer research - 15 Apr 2021

Rieunier Guillaume, Wu Xiaoning, Harris Letitia E, Mills Jack V, Nandakumar Ashwin, Colling Laura, Seraia Elena, Hatch Stephanie B, Ebner Daniel V, Folkes Lisa K, Weyer-Czernilofsky Ulrike, Bogenrieder Thomas, Ryan Anderson J, Macaulay Valentine M

Abstract excerpt

Inhibition of IGF receptor (IGF1R) delays repair of radiation-induced DNA double-strand breaks (DSB), prompting us to investigate whether IGF1R influences endogenous DNA damage. Here we demonstrate that IGF1R inhibition generates endogenous DNA lesions protected by 53BP1 bodies, indicating under-replicated DNA. In cancer cells, inhibition or depletion of IGF1R delayed replication fork progression accompanied by...

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Identifiers

PMID: 33509941
DOI: 10.1158/0008-5472.CAN-20-2860

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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