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Article

mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolism

29 Mar 2019

Abstract excerpt

Aging leads to skeletal muscle atrophy (i.e., sarcopenia), and muscle fiber loss is a critical component of this process. The mechanisms underlying these age-related changes, however, remain unclear. We show here that mTORC1 signaling is activated in a subset of skeletal muscle fibers in aging mouse and human, colocalized with fiber damage. Activation of mTORC1 in TSC1 knockout mouse muscle fibers increases the...

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PMID: 30924297
DOI: 10.1111/acel.12943

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