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Article

COPS3 AS lncRNA enhances myogenic differentiation and maintains fast-type myotube phenotype.

Cellular signalling - 1 Jul 2022

He Zhao Zhao, Zhao Tiantian, Qimuge Naren, Tian Tingting, Yan Wenyong, Yi Xudong, Jin Jianjun, Cai Rui, Yu Taiyong, Yang Gongshe, Pang Weijun

Abstract excerpt

Long non-coding RNAs (lncRNAs) play essential roles in myogenesis. Here, we identified a novel long non-coding RNA, named COPS3 AS lncRNA (COP9 signalosome complex subunit 3 antisense lncRNA), which was transcribed from the mouse COPS3 gene antisense strand and highly expressed in glycolytic muscle fibers. Functionally, COPS3 AS lncRNA knockdown inhibited myogenic differentiation in myoblasts, whereas its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35491006
DOI: 10.1016/j.cellsig.2022.110341

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