Article
Allele-specific epigenome maps reveal sequence-dependent stochastic switching at regulatory loci.
Science (New York, N.Y.) - 28 Sept 2018
Onuchic Vitor, Lurie Eugene, Carrero Ivenise, Pawliczek Piotr, Patel Ronak Y, Rozowsky Joel, Galeev Timur, Huang Zhuoyi, Altshuler Robert C, Zhang Zhizhuo, Harris R Alan, Coarfa Cristian, Ashmore Lillian, Bertol Jessica W, Fakhouri Walid D, Yu Fuli, Kellis Manolis, Gerstein Mark, Milosavljevic Aleksandar
Abstract excerpt
To assess the impact of genetic variation in regulatory loci on human health, we constructed a high-resolution map of allelic imbalances in DNA methylation, histone marks, and gene transcription in 71 epigenomes from 36 distinct cell and tissue types from 13 donors. Deep whole-genome bisulfite sequencing of 49 methylomes revealed sequence-dependent CpG methylation imbalances at thousands of heterozygous...
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