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Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity

4 Apr 2018

Abstract excerpt

HIV-1 causes chronic inflammation and AIDS in humans, whereas related simian immunodeficiency viruses (SIVs) replicate efficiently in their natural hosts without causing disease. It is currently unknown to what extent virus-specific properties are responsible for these different clinical outcomes. Here, we incorporate two putative HIV-1 virulence determinants, i.e., a Vpu protein that antagonizes tetherin and...

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PMID: 29636452
DOI: 10.1038/s41467-018-03762-3

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