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Physical activity and<i>APOE</i>neuropathology score modify the association of age and [<sup>11</sup>C]-PiB-PET amyloid burden in a cohort enriched with risk for Alzheimer’s disease

2025-03-05

Abstract excerpt

<h4>Background</h4> Physical activity (PA) is a protective factor against amyloid-β (Aβ) accumulation in adults at risk for Alzheimer’s disease (AD). This association, however, may differ by apolipoprotein E ( APOE ) genotype. This work examines interactions between age, PA, and neuropathology-based genetic risk for AD ( APOE np ) on Aβ burden in cortical regions sensitive to its accumulation. <h4>Materials and Me...

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Literature Corpus work
82da74c8-e056-5be2-bc6f-4293036188dd
DOI
10.1101/2025.03.01.25323157
Open publication

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Physical activity and<i>APOE</i>neuropathology score modify the association of age and [<sup>11</sup>C]-PiB-PET amyloid burden in a cohort enriched with risk for Alzheimer’s diseaseDOI 10.1101/2025.03.01.25323157
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