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Article

High-throughput screening of antibody variants for chemical stability: identification of deamidation-resistant mutants.

mAbs - 1 Oct 2018

DiCara Danielle M, Andersen Nisana, Chan Ruby, Ernst James A, Ayalon Gai, Lazar Greg A, Agard Nicholas J, Hilderbrand Amy, Hötzel Isidro

Abstract excerpt

Developability assessment of therapeutic antibody candidates assists drug discovery by enabling early identification of undesirable instabilities. Rapid chemical stability screening of antibody variants can accelerate the identification of potential solutions. We describe here the development of a high-throughput assay to characterize asparagine deamidation. We applied the assay to identify a mutation that...

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Identifiers

PMID: 30130444
DOI: 10.1080/19420862.2018.1504726
PMCID: PMC6204805

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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