Article
Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model.
Nature neuroscience - 1 Sept 2018
Locatelli Giuseppe, Theodorou Delphine, Kendirli Arek, Jordão Marta Joana Costa, Staszewski Ori, Phulphagar Kshiti, Cantuti-Castelvetri Ludovico, Dagkalis Athanasios, Bessis Alain, Simons Mikael, Meissner Felix, Prinz Marco, Kerschensteiner Martin
Abstract excerpt
Mononuclear phagocytes are key regulators of both tissue damage and repair in neuroinflammatory conditions such as multiple sclerosis. To examine divergent phagocyte phenotypes in the inflamed CNS, we introduce an in vivo imaging approach that allows us to temporally and spatially resolve the evolution of phagocyte polarization in a murine model of multiple sclerosis. We show that the initial proinflammatory...
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