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Article

SERCA is critical to control the Bowditch effect in the heart.

Scientific reports - 20 Aug 2018

Balcazar Darío, Regge Victoria, Santalla Manuela, Meyer Heiko, Paululat Achim, Mattiazzi Alicia, Ferrero Paola

Abstract excerpt

The Bowditch effect or staircase phenomenon is the increment or reduction of contractile force when heart rate increases, defined as either a positive or negative staircase. The healthy and failing human heart both show positive or negative staircase, respectively, but the causes of these distinct cardiac responses are unclear. Different experimental approaches indicate that while the level of Ca2+ in the...

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Source

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Identifiers

PMID: 30127403
DOI: 10.1038/s41598-018-30638-9
PMCID: PMC6102201

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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