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Article

Disruption of sarcoendoplasmic reticulum calcium ATPase function in Drosophila leads to cardiac dysfunction.

PloS one - 1 Jan 2013

Abraham Dennis M, Wolf Matthew J

Abstract excerpt

Abnormal sarcoendoplasmic reticulum Calcium ATPase (SERCA) function has been associated with poor cardiac function in humans. While modifiers of SERCA function have been identified and studied using animal models, further investigation has been limited by the absence of a model system that is amenable to large-scale genetic screens. Drosophila melanogaster is an ideal model system for the investigation of SERCA...

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Identifiers

PMID: 24098595
DOI: 10.1371/journal.pone.0077785
PMCID: PMC3789689

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