Mutations in and deletions of the Ca2+ channel-encoding gene cacophony, which affect courtship song in Drosophila, have novel effects on heartbeating.

Abstract excerpt

The cacophony (cac) locus of Drosophila melanogaster encodes the a-1 subunit of a voltage gated Ca(2+) channel, termed Dmca1A. A subset of mutations at this locus cause characteristic alterations in the male mating song, manifest as polycyclic pulses with higher than normal amplitude. This phenotype has been postulated to result from disruption of an oscillator involving the cac-encoded channel, nearly identical...

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