Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Critical assessment of approaches for molecular docking to elucidate associations of HLA alleles with adverse drug reactions.

Molecular immunology - 1 Sept 2018

Ramsbottom Kerry A, Carr Daniel F, Jones Andrew R, Rigden Daniel J

Abstract excerpt

Adverse drug reactions have been linked with genetic polymorphisms in HLA genes in numerous different studies. HLA proteins have an essential role in the presentation of self and non-self peptides, as part of the adaptive immune response. Amongst the associated drugs-allele combinations, anti-HIV drug Abacavir has been shown to be associated with the HLA-B*57:01 allele, and anti-epilepsy drug Carbamazepine with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carbamazepine
Share to Dideoxynucleosides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug-Related Side Effects and Adverse Reactions

Share to HLA Antigens

Share to Molecular Docking Simulation

Share to Peptides

Share to Software

Share to Structural Homology, Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 30125869
DOI: 10.1016/j.molimm.2018.08.003
PMCID: PMC6148408

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Critical assessment of approaches for molecular docking to elucidate associations of HLA alleles with adverse drug reactions.PMID 30125869Read ↗

Molecular docking to investigate HLA-associated idiosyncratic drug reactionsSemantic proximity Read ↗

Informatics investigations into HLA-mediated adverse drug reactionsSemantic proximity Read ↗

Adverse drug reactions triggered by the common HLA-B*57:01 variant: a molecular docking studySemantic proximity Read ↗

Immunopharmacogenomics: Mechanisms of HLA-Associated Drug Reactions.Semantic proximity Read ↗

Implementing computational techniques to investigate immune-mediated adverse drug reactionsSemantic proximity Read ↗

Informatics investigations into anti-thyroid drug induced agranulocytosis associated with multiple HLA-B allelesSemantic proximity Read ↗

Human leukocyte antigen (HLA) pharmacogenomic tests: potential and pitfalls.Semantic proximity Read ↗

Informatics investigations into anti-thyroid drug induced agranulocytosis associated with multiple HLA-B alleles.Semantic proximity Read ↗

HLA-associated drug hypersensitivity and the prediction of adverse drug reactions.Semantic proximity Read ↗

[Importance of HLA in Determining Individual Differences in the Onset of Adverse Drug Reactions].Semantic proximity Read ↗

HLA Allele-Restricted Immune-Mediated Adverse Drug Reactions: Framework for Genetic Prediction.Semantic proximity Read ↗

Progress in study on the association between HLA genetic variation and adverse drug reactions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.