Article
Peptidoglycan recycling contributes to intrinsic resistance to fosfomycin in Acinetobacter baumannii.
The Journal of antimicrobial chemotherapy - 1 Nov 2018
Gil-Marqués María Luisa, Moreno-Martínez Patricia, Costas Coloma, Pachón Jerónimo, Blázquez Jesús, McConnell Michael J
Abstract excerpt
Background: Acinetobacter baumannii is intrinsically resistant to fosfomycin; however, the mechanisms underlying this resistance are poorly understood. Objectives: To identify and characterize genes that contribute to intrinsic fosfomycin resistance in A. baumannii. Methods: More than 9000 individual transposon mutants of the A. baumannii ATCC 17978 strain (fosfomycin MIC ≥1024 mg/L) were screened to identify...
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