Article
Insertion sequence transposition determines imipenem resistance in Acinetobacter baumannii.
Microbial drug resistance (Larchmont, N.Y.) - 1 Oct 2014
Kuo Han-Yueh, Chang Kai-Chih, Liu Chih-Chin, Tang Chuan Yi, Peng Jhih-Hua, Lu Chia-Wei, Tu Chi-Chao, Liou Ming-Li
Abstract excerpt
This study employed genomewide analysis to investigate potential resistance mechanisms in Acinetobacter baumannii following imipenem exposure. Imipenem-selected mutants were generated from the imipenem-susceptible strain ATCC 17978 by multistep selection resistance. Antibiotic susceptibilities were examined, and the selected mutants originated from the ATCC 17978 strain were confirmed by pulsed-field gel...
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