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Transcriptional network analysis of human astrocytic endfoot genes reveals region-specific associations with dementia status and tau pathology

13 Aug 2018

Abstract excerpt

The deposition of misfolded proteins, including amyloid beta plaques and neurofibrillary tangles is the histopathological hallmark of Alzheimer's disease (AD). The glymphatic system, a brain-wide network of perivascular pathways that supports interstitial solute clearance, is dependent upon expression of the perivascular astroglial water channel aquaporin-4 (AQP4). Impairment of glymphatic function in the aging...

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PMID: 30120299
DOI: 10.1038/s41598-018-30779-x

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