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Article

Tissue-specific effects of targeted mutation of Mir29b1 in rats.

EBioMedicine - 1 Sept 2018

Xue Hong, Zhang Guangyuan, Geurts Aron M, Usa Kristie, Jensen David M, Liu Yong, Widlansky Michael E, Liang Mingyu

Abstract excerpt

BACKGROUND: miR-29 is a master regulator of extracellular matrix genes, but conflicting data on its anti-fibrotic effect have been reported. miR-29 improves nitric oxide (NO) production in arterioles by targeting Lypla1. Mir29b1 targeted mutation exacerbates hypertension in a model derived from the Dahl salt-sensitive rat. We examined the effect of Mir29b1 mutation on tissue fibrosis and NO levels with a focus on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30120082
DOI: 10.1016/j.ebiom.2018.08.016
PMCID: PMC6156712

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