Article
miR-29 is an important driver of aging-related phenotypes.
Communications biology - 27 Aug 2024
Swahari Vijay, Nakamura Ayumi, Hollville Emilie, Hung Yu-Han, Kanke Matt, Kurtz C Lisa, Caravia Xurde M, Roiz-Valle David, He Shenghui, Krishnamurthy Janakiraman, Kapoor Sahil, Prasad Varun, Flowers Cornelius, Beck Matt, Baran-Gale Jeanette, Sharpless Norman, López-Otín Carlos, Sethupathy Praveen, Deshmukh Mohanish
Abstract excerpt
Aging is a consequence of complex molecular changes, but whether a single microRNA (miRNA) can drive aging remains unclear. A miRNA known to be upregulated during both normal and premature aging is miR-29. We find miR-29 to also be among the top miRNAs predicted to drive aging-related gene expression changes. We show that partial loss of miR-29 extends the lifespan of Zmpste24-/- mice, an established model of...
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