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Article

Hypoxia promotes acquisition of aggressive phenotypes in human malignant mesothelioma

15 Aug 2018

Abstract excerpt

BACKGROUND: Hypoxia is a hallmark of the solid tumor microenvironment and is associated with poor outcomes in cancer patients. The present study was performed to investigate mechanisms underlying the hypoxia-induced phenotypic changes using human malignant mesothelioma (HMM) cells. METHODS: Hypoxic conditions were achieved by incubating HMM cells in the air chamber. The effect of hypoxia on phenotype changes in...

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PMID: 30111297
DOI: 10.1186/s12885-018-4720-z

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