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Article

E-Cadherin loss associated with EMT promotes radioresistance in human tumor cells.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Jun 2011

Theys Jan, Jutten Barry, Habets Roger, Paesmans Kim, Groot Arjan J, Lambin Philippe, Wouters Brad G, Lammering Guido, Vooijs Marc

Abstract excerpt

BACKGROUND AND PURPOSE: Hypoxia is a hallmark of solid cancers and associated with metastases and treatment failure. During tumor progression epithelial cells often acquire mesenchymal features, a phenomenon known as epithelial-to-mesenchymal transition (EMT). Intratumoral hypoxia has been linked to EMT induction. We hypothesized that signals from the tumor microenvironment such as growth factors and tumor...

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Source

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Identifiers

PMID: 21680037
DOI: 10.1016/j.radonc.2011.05.044
PMCID: PMC4948667

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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