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Article

Hypoxia-induced dedifferentiation of tumor cells--a mechanism behind heterogeneity and aggressiveness of solid tumors.

Seminars in cell & developmental biology - 1 Jan 2000

Axelson Håkan, Fredlund Erik, Ovenberger Marie, Landberg Göran, Påhlman Sven

Abstract excerpt

Histopathological examination of solid tumors frequently reveals pronounced tumor cell heterogeneity with regards to cell organization, cell morphology, cell size, nuclei morphology, etc. Analyses of gene expression patterns by immunohistochemistry or in situ hybridization techniques further stre...

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Source

Identifiers

PMID: 16144692
DOI: 10.1016/j.semcdb.2005.03.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16144692-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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