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Article

Enhanced Pathogenic Consequences Induced by a Seven-Amino-Acid Extension in the G Protein of the HRSV BA9 Genotype.

International journal of molecular sciences - 27 Feb 2025

Wang Na, Song Jingjing, Cao Lei, Mao Naiying, Shi Yuqing, Jiang Jie, Zhu Wuyang, Zhang Yan

Abstract excerpt

In a previous outbreak of the human respiratory syncytial virus (HRSV), we identified a variant strain of genotype BA9 with a seven-amino-acid extension (Q-R-L-Q-S-Y-A) at the C-terminus of the attachment protein (G). To assess the impact of this extension on the virulence of HRSV, two full-length infectious clones using the wild strain of genotype BA9 as a backbone, one containing the seven-amino-acid extension...

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Identifiers

PMID: 40076707
DOI: 10.3390/ijms26052081
PMCID: PMC11900327

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