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Article

Tmc2 expression partially restores auditory function in a mouse model of DFNB7/B11 deafness caused by loss of Tmc1 function.

Scientific reports - 14 Aug 2018

Nakanishi Hiroshi, Kurima Kiyoto, Pan Bifeng, Wangemann Philine, Fitzgerald Tracy S, Géléoc Gwenaëlle S, Holt Jeffrey R, Griffith Andrew J

Abstract excerpt

Mouse Tmc1 and Tmc2 are required for sensory transduction in cochlear and vestibular hair cells. Homozygous Tmc1∆/∆ mice are deaf, Tmc2∆/∆ mice have normal hearing, and double homozygous Tmc1∆/∆; Tmc2∆/∆ mice have deafness and profound vestibular dysfunction. These phenotypes are consistent with their different spatiotemporal expression patterns. Tmc1 expression is persistent in cochlear and vestibular hair...

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Share to Hearing Loss, Sensorineural

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mechanotransduction, Cellular

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Identifiers

PMID: 30108230
DOI: 10.1038/s41598-018-29709-8
PMCID: PMC6092339

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