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Article

Absence of complement factor H alters bone architecture and dynamics.

Immunobiology - 1 Dec 2018

Alexander Jessy J, Sankaran Jeyantt S, Seldeen Kenneth L, Thiyagarajan Ramkumar, Jacob Alexander, Quigg Richard J, Troen Bruce R, Judex Stefan

Abstract excerpt

Complement system is an important arm of the immune system that promotes inflammation. Complement Factor H (FH) is a critical regulator of the alternative complement pathway. Its absence causes pathology in different organs resulting in diseases such as age related macular degeneration and dense deposit disease. Recent studies suggest that the complement system plays a role in bone development and homeostasis. To...

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Identifiers

PMID: 30107932
DOI: 10.1016/j.imbio.2018.07.023

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