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Complement C3 deficiency inhibits osteoclast differentiation and prevents ovariectomy-induced osteoporosis

22 Aug 2025

Abstract excerpt

The pathomechanistic role of the complement system is well recognized in various pathological conditions affecting bone tissues and the bone microenvironment, including rheumatoid arthritis, osteoarthritis, bone fractures, and periodontitis. The homeostasis of the bone is maintained by continuous remodeling, in which bone-resorbing or demineralizing osteoclast cells remove bone calcification, and osteoblast cells...

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PMID: 40847478
DOI: 10.1093/jimmun/vkaf180

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