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Article

Pirt reduces bladder overactivity by inhibiting purinergic receptor P2X3.

Nature communications - 7 Jul 2015

Gao Xiao-Fei, Feng Ji-Feng, Wang Wei, Xiang Zheng-Hua, Liu Xiu-Jie, Zhu Chan, Tang Zong-Xiang, Dong Xin-Zhong, He Cheng

Abstract excerpt

Pirt is a transmembrane protein predominantly expressed in peripheral neurons. However, the physiological and pathological roles of Pirt in hollow viscus are largely unknown. Here we show that Pirt deficiency in mice causes bladder overactivity. The density of α,β-meATP-induced currents is significantly reinforced in Pirt-deficient dorsal root ganglion (DRG) neurons. Pirt and P2X3 receptor co-localize in bladder...

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PMID: 26151598
DOI: 10.1038/ncomms8650

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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