Article
The consequences of cavity creation on the folding landscape of a repeat protein depend upon context.
Proceedings of the National Academy of Sciences of the United States of America - 28 Aug 2018
Jenkins Kelly A, Fossat Martin J, Zhang Siwen, Rai Durgesh K, Klein Sean, Gillilan Richard, White Zackary, Gerlich Grayson, McCallum Scott A, Winter Roland, Gruner Sol M, Barrick Doug, Royer Catherine A
Abstract excerpt
The effect of introducing internal cavities on protein native structure and global stability has been well documented, but the consequences of these packing defects on folding free-energy landscapes have received less attention. We investigated the effects of cavity creation on the folding landscape of the leucine-rich repeat protein pp32 by high-pressure (HP) and urea-dependent NMR and high-pressure small-angle...
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