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Article

Effects of Mutations on Tandem-Repeat Proteins Conformation Mechanisms. Application to the Phosphatase PP2A.

Journal of chemical information and modeling - 13 Apr 2026

Chiappinelli Matias, Saldaño Tadeo E, Tosatto Silvio C E, Grudinin Sergei, Parisi Gustavo, Fernandez-Alberti Sebastian

Abstract excerpt

Tandem repeat proteins (TRPs) are composed of arrays of repeating structural units that assemble into extended, superhelical, or horseshoe-shaped architectures stabilized primarily by short-range interactions. The unique sequence-structure-dynamics-function relationships of TRPs have been the subject of extensive investigation, aiming to elucidate the molecular principles that distinguish them from globular...

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PMID: 41855533
DOI: 10.1021/acs.jcim.6c00133

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