Article
Molecular determinants of expansivity of native globular proteins: a pressure perturbation calorimetry study.
The journal of physical chemistry. B - 12 Jun 2014
Vasilchuk Daniel, Pandharipande Pranav P, Suladze Saba, Sanchez-Ruiz Jose M, Makhatadze George I
Abstract excerpt
There is a growing interest in understanding how hydrostatic pressure (P) impacts the thermodynamic stability (ΔG) of globular proteins. The pressure dependence of stability is defined by the change in volume upon denaturation, ΔV = (∂ΔG/∂P)T. The temperature dependence of change in volume upon denaturation itself is defined by the changes in thermal expansivity (ΔE), ΔE = (∂ΔV/∂T)P. The pressure perturbation...
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