Article
Filling a cavity dramatically increases pressure stability of the c-Myb R2 subdomain.
Proteins - 1 Oct 2001
Lassalle M W, Yamada H, Morii H, Ogata K, Sarai A, Akasaka K
Abstract excerpt
Cavities or packing defects in proteins may generally be related with the dynamics and function of a protein. In the c-Myb R2 subdomain, its single cavity has been shown to be crucial for its DNA recognition. Cavities are also considered important in determining the pressure stability of a protein. In the present work, high-pressure proton nuclear magnetic resonance ((1)H NMR) spectroscopy at 750 MHz is used to...
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