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Article

Structure-relaxation mechanism for the response of T4 lysozyme cavity mutants to hydrostatic pressure.

Proceedings of the National Academy of Sciences of the United States of America - 12 May 2015

Lerch Michael T, López Carlos J, Yang Zhongyu, Kreitman Margaux J, Horwitz Joseph, Hubbell Wayne L

Abstract excerpt

Application of hydrostatic pressure shifts protein conformational equilibria in a direction to reduce the volume of the system. A current view is that the volume reduction is dominated by elimination of voids or cavities in the protein interior via cavity hydration, although an alternative mechanism wherein cavities are filled with protein side chains resulting from a structure relaxation has been suggested...

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Identifiers

PMID: 25918400
DOI: 10.1073/pnas.1506505112
PMCID: PMC4434698

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